Description of the Project: My current research focuses on understanding the immune interplay responsible for the clearance of human papillomavirus (HPV) in women, using the female sex workers from the Sex Workers Outreach Program (SWOP) in Kenya as a cohort. My research aims to examine the memory T cells to HPV recall antigens of women who can clear HPV infection to suggest a novel approach for the HPV therapeutic vaccine for the reduction of HPVrelated cervical cancer (CC). HPV is a prevalent sexually transmitted infection worldwide, affecting over 80% of sexually active individuals and it is a leading cause of CC globally with over 600,000 women diagnosed with HPV-related cancer in 2020 and more than 340, 000 deaths. However, achieving vaccination targets to eliminate CC globally remains challenging due to low vaccine uptake in many regions, including Kenya. This study aims to inform therapeutic vaccine development, potentially reducing HPV-related cervical cancer diseases to improve women’s health around the world.