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Dr. Sandeep Thirunavukkarasu
Home Country: Bangalore, India
Degrees:

MBBS Ramaiah Medical College, Rajiv Gandhi University Of Health Sciences, Karnataka, India

MBA (Hospital Management) Indian Institute of Pharmaceutical Marketing, India

MD (Microbiology) Ambedkar Medical College, Rajiv Gandhi University of Health Sciences, Karnataka, India

MMSc (Infectious Diseases) University of Nicaragua, Guyana

Supervisor:

Project Title:

Dr. Medha. Y. Rao

Clinical outcome in ICU patients after de-escalation of antibiotics based on selective reporting strategy

Description of the Project: Sepsis, the syndrome of life-threatening organ dysfunction complicating severe infection, requires early active antibiotic therapy is associated with better outcomes. Antimicrobial de-escalation is commonly recommended in the intensive care unit (ICU) patients who are treated with broad-spectrum antibiotics, as a strategy to reduce antimicrobial pressure of empirical broad-spectrum therapy and prevent antimicrobial resistance, yet this has not been convincingly demonstrated in a clinical setting. Selective reporting of antibiotic susceptibility testing (AST) results is a potentially interesting tool for antibiotic stewardship. Evidence shows selective reporting is able to influence antibiotic use, both discouraging prescription in case of colonization, and promoting the selection of narrow-spectrum agents. Aim of the study is to estimate the frequency of de-escalation of antibiotics in ICU based on culture reports with selective reporting strategy & to calculate the reduction in days of hospitalization. Expected outcomes are appropriate prescription of antibiotics for infections, judicious use of antibiotics in the ICU, significant reduction in cost to the patient during the hospital stay & increased cure rate of infections encountered in ICU.

University of Manitoba
University of Nairobi
Canadian Institute of Health Research
Canadian Institute of Health Research
Ramaiah University of Applied Sciences
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